Detailed Maprotiline HCL Description:
Maprotiline has been shown to exhibit an antidepressant action. It strongly inhibits the uptake of noradrenaline in the brain and peripheral tissues, though it is notable in its lack of inhibition of serotonergic uptake. It has markedly less pronounced alpha adrenergic blocking activity than amitriptyline. A strong antihistaminic and a weaker anticholinergic action are seen in the pharmacological profile of maprotiline. Maprotiline also exerts a sedative effect on the anxiety component of depressive illness.
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